An action potential propagation in guinea pig heart. The heart was Langendorff perfuse and stained with PGH1. The anterior surface of heart was focused on 100x100 CMOS chip with 0.15x0.15 mm2 spatial resolution. The heart was stimulated from the left side of view and action potential propagation was recorded at 10,000 frames/second. The first derivative of action potential was calculated to detect wave fronts as shown in this trace. The animation of action potential propagation clearly shows details of the direction and the curvature of the wave front.
- Provided by
- Dr.Guy Salama and Dr.Bum-Rak Choi, Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine